1501-84-4
- Product Name：Rimantadine hydrochloride
- Molecular Formula：C12H22ClN
- Purity：99%
- Molecular Weight：215.766
Product Details;
CasNo： 1501-84-4
Molecular Formula： C12H22ClN
Appearance： white crystalline solid
Buy Quality Trustworthy Manufacturer Supply Rimantadine hydrochloride 1501-84-4 with Safe Delivery
- Molecular Formula:C12H21N*ClH
- Molecular Weight:215.766
- Appearance/Colour:white crystalline solid
- Vapor Pressure:0.0251mmHg at 25°C
- Melting Point:>300 °C
- Boiling Point:247.8 °C at 760 mmHg
- Flash Point:99.3 °C
- PSA：26.02000
- LogP:4.05230
Rimantadine hydrochloride(Cas 1501-84-4) Usage
|
Description |
Rimantadine hydrochloride is an antiviral analogue of amantadine, reportedly useful in the prophylaxis and treatment of influenza A. Compared with amantadine, nmantadine appears to have a lower side-effect profile. |
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Chemical Properties |
White Crystalline Solid |
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Originator |
DuPont (USA) |
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Uses |
Rimantadine Hydrochloride is used as an antiviral agent. |
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Brand name |
Flumadine (Forest);Roflual. |
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references |
[1] koff w c, elm jr j l, halstead s b. suppression of dengue virus replication in vitro by rimantadine hydrochloride[j]. the american journal of tropical medicine and hygiene, 1981, 30(1): 184-189.[2] koff w c, peavy d l, knight v. inhibition of in vitro proliferative responses of human lymphocytes by rimantadine hydrochloride[j]. infection and immunity, 1979, 23(3): 665-669.[3] hayden f g, monto a s. oral rimantadine hydrochloride therapy of influenza a virus h3n2 subtype infection in adults[j]. antimicrobial agents and chemotherapy, 1986, 29(2): 339-341. |
InChI:InChI=1/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H
1501-84-4 Relevant articles
Preparation method of rimantadine hydrochloride preparation
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Paragraph 0026; 0033; 0042; 0051, (2019/02/04)
The invention discloses a preparation me...
Synthesizing method of rimantadine hydrochloride
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Paragraph 0022; 0025; 0032; 0040; 0048, (2019/02/21)
The invention discloses a synthesizing m...
A kind of anti-influenza virus preparation
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Paragraph 0026; 0033; 0042; 0051, (2019/03/15)
The present invention discloses an anti-...
Process for preparing rimantadine
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, (2008/06/13)
A low temperature and pressure process f...
1501-84-4 Process route
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1707-40-0
1-((3r,5r,7r)-adamantan-1-yl)ethan-1-one oxime
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1501-84-4,33122-80-4,33122-81-5,33298-76-9
rimantadine hydrochloride
| Conditions | Yield |
|---|---|
|
1-((3r,5r,7r)-adamantan-1-yl)ethan-1-one oxime;
With
palladium on activated charcoal; hydrogen; acetic acid;
at 20 ℃;
for 18h;
under 3000.3 Torr;
Autoclave;
With
hydrogenchloride;
In
water;
Pressure;
|
95% |
|
1-((3r,5r,7r)-adamantan-1-yl)ethan-1-one oxime;
With
L-Tartaric acid; palladium on activated charcoal; hydrogen; acetic acid;
at 20 ℃;
for 18h;
under 3000.3 Torr;
Autoclave;
Green chemistry;
With
hydrogenchloride;
Pressure;
Reagent/catalyst;
Green chemistry;
|
95% |
|
1-((3r,5r,7r)-adamantan-1-yl)ethan-1-one oxime;
With
metatartaric acid; palladium on activated charcoal; hydrogen; acetic acid;
at 20 ℃;
for 18h;
under 3000.3 Torr;
Autoclave;
With
hydrogenchloride;
Pressure;
|
95% |
-
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78679-71-7
1-adamantyl methyl ketoxime
-
-
1501-84-4,33122-80-4,33122-81-5,33298-76-9
rimantadine hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; hydrogen;
Pt/C;
In
dichloromethane; water; acetic acid; ethyl acetate;
|
75% |
|
With
hydrogenchloride;
Pt/C;
In
ethanol; water;
|
1501-84-4 Upstream products
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78679-71-7
1-adamantyl methyl ketoxime
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1707-40-0
1-((3r,5r,7r)-adamantan-1-yl)ethan-1-one oxime
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281-23-2
adamantane
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768-90-1
1-Adamantyl bromide
1501-84-4 Downstream products
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90812-24-1
3-(1-aminoethyl)adamantan-1-ol hydrochloride
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