89797-68-2
- Product Name：5-(Ethylthio)-1H-tetrazole
- Molecular Formula：C3H6N4S
- Purity：99%
- Molecular Weight：130.173
Product Details;
CasNo： 89797-68-2
Molecular Formula： C3H6N4S
Appearance： White crystals
High Purity 99% Factory Supply High Purity 5-(Ethylthio)-1H-tetrazole 89797-68-2 In Stock
- Molecular Formula:C3H6N4S
- Molecular Weight:130.173
- Appearance/Colour:White crystals
- Vapor Pressure:0.00184mmHg at 25°C
- Melting Point:72-80 °C(lit.)
- Refractive Index:1.574
- Boiling Point:292.3 °C at 760 mmHg
- PKA:3.89±0.10(Predicted)
- Flash Point:130.6 °C
- PSA：79.76000
- Density:1.37 g/cm3
- LogP:0.31170
5-(Ethylthio)-1H-tetrazole(Cas 89797-68-2) Usage
|
Chemical Properties |
White crystals |
|
Application |
5-(Ethylthio)-1H-tetrazole is used a powerful activator in DNA and RNA syntheses. |
|
Preparation |
5-(Ethylthio)-1H-Tetrazole is prepared from the corresponding alkyl thiocyanate and sodium azide through a [2?+?3] cycloaddition under phase transfer catalytic conditions (eq 1). The ratio of the solvent (water to toluene) as well as the reaction temperature are important factors in obtaining preparative yields of the alkylthiotetrazoles. 5-Ethylthio-1H-tetrazole has also been prepared using DMF as solvent albeit in much lower yield. |
|
General Description |
5-(Ethylthio)-1H-tetrazole (ETT) is an efficient activator, that activates nucleoside phosphoramidites towards condensation with a nucleoside to form dinucleoside phosphates during oligonucleotide synthesis. |
|
Purification Methods |
recrystallized from toluene. |
InChI:InChI=1/C3H6N4S/c1-2-8-3-4-6-7-5-3/h2H2,1H3,(H,4,5,6,7)
89797-68-2 Relevant articles
A zinc Lewis acid surface active agent for the preparation of 5' - substituted tetrazole compounds
-
Paragraph 0052-0060, (2018/09/08)
The invention belongs to the field of or...
Preparation of 5-alkylthio and 5-arylthiotetrazoles from thiocyanates using phase transfer catalysis
LeBlanc, Blaise W.,Jursic, Branko S.
, p. 3591 - 3599 (2007/10/03)
A very efficient method of preparation f...
89797-68-2 Process route
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542-90-5
ethyl isothiocyanate
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-
89797-68-2
5-(ethylthio)-1H-tetrazole
| Conditions | Yield |
|---|---|
|
ethyl isothiocyanate;
With
sodium azide;
In
water;
at 20 ℃;
for 0.5h;
With
hydrogen bromide;
In
water;
pH=1-2;
|
92% |
|
With
sodium azide; ammonium chloride; cetyltrimethylammonim bromide;
In
water; toluene;
at 75 ℃;
for 85h;
|
63% |
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-
89797-68-2
5-(ethylthio)-1H-tetrazole
| Conditions | Yield |
|---|---|
|
Ethylthiocyanat 1. NaN3 in sd.DMF 2. NH4Cl, 3 h;
|
|
|
(yield)50percent;
|
|
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Ethylthiocyanat, NaN3, NH4Cl, in Dioxan+W., 89grad, 6 h;
|
|
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(yield)15percent;
|
89797-68-2 Upstream products
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542-90-5
ethyl isothiocyanate
89797-68-2 Downstream products
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114006-53-0
(5-Ethylsulfanyl-tetrazol-1-yl)-(2,4,6-trimethyl-phenyl)-methanone oxime
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