What is the BETA-PSEUDOURIDINE?

BETA-PSEUDOURIDINE is , while it's Molecular Formula is C9H12N2O6. An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.

What is the CAS number for BETA-PSEUDOURIDINE?

The CAS number of BETA-PSEUDOURIDINE is 1445-07-4.

What is BETA-PSEUDOURIDINE (1445-07-4) used for?

β-Pseudouridine is the C-5 glycoside isomer of the nucleoside uridine . It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. β-pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes. In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner.InChI:InChI=1/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1

What is the BETA-PSEUDOURIDINE?

BETA-PSEUDOURIDINE is , while it's Molecular Formula is C9H12N2O6. An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.

What is the CAS number for BETA-PSEUDOURIDINE?

The CAS number of BETA-PSEUDOURIDINE is 1445-07-4.

What is BETA-PSEUDOURIDINE (1445-07-4) used for?

β-Pseudouridine is the C-5 glycoside isomer of the nucleoside uridine . It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. β-pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes. In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner.InChI:InChI=1/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1

Product classification

1445-07-4

Product Name：Pseudouridine
Molecular Formula：C₉H₁₂N₂O₆
Purity：99%
Molecular Weight：244.204

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Product Details;

CasNo： 1445-07-4

Molecular Formula： C₉H₁₂N₂O₆

Factory Supply 99% Pure Pseudouridine 1445-07-4 with Cheap Price

Molecular Formula:C9H12N2O6
Molecular Weight:244.204
Vapor Pressure:3.63E-15mmHg at 25°C
Melting Point:222 °C
Refractive Index:1.623
Boiling Point:598.4 °C at 760 mmHg
PKA:8.52±0.10(Predicted)
Flash Point:315.7 °C
PSA：135.64000
Density:1.641 g/cm³
LogP:-2.78280

BETA-PSEUDOURIDINE(Cas 1445-07-4) Usage

Description	β-Pseudouridine is the C-5 glycoside isomer of the nucleoside uridine . It is formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme. β-pseudouridine is found in tRNAs from bacteria, archaea, and eukaryotes. In vitro, it reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner.
Uses	An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specific uridine residues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.
Definition	ChEBI: A C-glycosyl pyrimidine that consists of uracil having a beta-D-ribofuranosyl residue attached at position 5. The C-glycosyl isomer of the nucleoside uridine.

InChI:InChI=1/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/m1/s1

1445-07-4 Relevant articles

Total synthesis of pseudouridine: Via Heck-type C-glycosylation

Yu, Cheng-Ping,Chang, Hsin-Yun,Chien, Tun-Cheng

, p. 8796 - 8803 (2019)

The reaction of 2,4-dimethoxy-5-iodopyri...

Semi-enzymatic synthesis of pseudouridine

Clerc, Elliot P.,Riley, Andrew T.,Sanford, Tristan C.,Sumita, Minako,Woodard, Austin M.

, (2021)

Modifications of RNA molecules have a si...

-

Brown et al.

, p. 1051 (1968)

Structural elucidation of bisulfite adducts to pseudouridine that result in deletion signatures during reverse transcription of RNA

Fleming, Aaron M.,Alenko, Anton,Kitt, Jay P.,Orendt, Anita M.,Flynn, Peter F.,Harris, Joel M.,Burrows, Cynthia J.

, p. 16450 - 16460 (2019)

The recent report of RBS-Seq to map simu...

An arginine-aspartate network in the active site of bacterial TruB is critical for catalyzing pseudouridine formation

Friedt, Jenna,Leavens, Fern M. V.,Mercier, Evan,Wieden, Hans-Joachim,Kothe, Ute

, p. 3857 - 3870 (2014)

Pseudouridine synthases introduce the mo...

-

Asbun,W.,Binkley,S.B.

, p. 140 - 142 (1968)

Total Synthesis of Pseudouridimycin

Jia, Yue-Mei,Li, Yi-Xian,Wang, Xu-Kun,Yu, Chu-Yi

, p. 511 - 515 (2022/01/28)

Pseudouridimycin (1), a potent antibioti...

1445-07-4 Process route

: 28113-58-8
5-(2,3-O-isopropylidene-β-D-ribofuranosyl)uracil

: 1445-07-4
pseudouridine

Conditions

Conditions	Yield
With hydrogenchloride; In methanol; at 20 ℃; for 5h;	93%

: 57100-18-2
pseudoisocytidine

: 1445-07-4
pseudouridine

Conditions

Conditions	Yield
With acetic anhydride; In pyridine; ethyl acetate;	3.2 g (85%)

1445-07-4 Upstream products

64714-46-1
(1S)-tri-O-acetyl-1-(2,4-bis-methylsulfanyl-pyrimidin-5-yl)-D-1,4-anhydro-ribitol
67320-14-3
(1Ξ)-O²,O⁴;O³,O⁵-(R,R)-dibenzylidene-1-(2,4-bis-benzyloxy-pyrimidin-5-yl)-D-ribitol
28113-58-8
5-(2,3-O-isopropylidene-β-D-ribofuranosyl)uracil
78119-28-5
5-((3S,4R,5R)-3,4-Dimethoxy-5-methoxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione