Product Details;
CasNo: 71-30-7
Molecular Formula: C4H5N3O
Appearance: white solid
Wholesale Quality Manufacturer Supply Cytosine 71-30-7 with Lowest Price
- Molecular Formula:C4H5N3O
- Molecular Weight:111.103
- Appearance/Colour:white solid
- Vapor Pressure:1.46E-08mmHg at 25°C
- Melting Point:>300 °C(lit.)
- Refractive Index:1.688
- Boiling Point:445.8 °C at 760 mmHg
- PKA:4.60, 12.16(at 25℃)
- Flash Point:223.4 °C
- PSA:71.77000
- Density:1.55 g/cm3
- LogP:-0.06670
Cytosine(Cas 71-30-7) Usage
Description |
Cytosine is pyrimidine; along with adenine and guanine they account for the fi ve nucleic acid bases. Pyrimidines are heterocyclic single-ringed compounds based on the structure of pyrimidine. Cytosinelike adenine and guanine, form nucleosides and nucleotides in RNA and DNA. When the bases combine with ribose, a ribonucleoside forms; and when it attaches to deoxyribose, a deoxyribosenucleoside is formed. Names of the nucleoside are summarized in Table 29.1.these in turn combine with phosphoryl groups, in a process called phosphorylation, to form their respective nucleotides that form nucleic acids.the nucleotides can be tri, di, and mono phosphate nucleotides similar to the way in which adenine forms ATP, ADP, and AMP. |
Chemical Properties |
White Solid |
History |
Cytosine is first isolated by hydrolysis of calf thymus tissue by Albrecht Kossel (1853–1927) and A. Neumann during 1893–1894. Thymine’s structure was published in 1900 and confi rmed over the next several years when it was synthesized by several investigators. In 1903, cytosine was synthesized by Henry Lord Wheeler (1867–1914) and Treat B. Johnson, confirming its structure. Uracil was first isolated in 1900 from yeast nucleic acid found in bovine thymus and herring sperm.the methylation of uracil produces thymine; thymine is also called 5-methyluracil because methylation takes place at the fi fth carbon in uracil to produce thymine. |
Uses |
Cytosine is a nucleoside used for proteomics research. It is also used as an enzyme substrate or precursor of effector molecules such as cytosine sugars. |
Definition |
ChEBI: An aminopyrimidine that is pyrimidin-2-one having the amino group located at position 4. |
General Description |
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
Biochem/physiol Actions |
Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA). |
Purification Methods |
Cytosine crystallises from H2O as the monohydrate which loses water on heating above 100o. Its solubility in H2O is 0.77%. UV: max 267nm ( 6,100) in H2O pH 8.8 and 275nm ( 10,400) in 0.1N HCl. [Hilbert & Johnson J Am Chem Soc 52 1152 1930, Hilbert et al. J Am Chem Soc 57 552 1935, Beistein 25 III/IV 3654.] |
InChI:InChI=1/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
71-30-7 Relevant articles
The aminomethylation of adenine, cytosine and guanine
Sloan,Siver
, p. 3997 - 4001 (1984)
-
A facile and effective synthesis of lamivudine 5′-diphosphate
Roy, Béatrice,Lefebvre, Isabelle,Puy, Jean-Yves,Périgaud, Christian
, p. 1250 - 1252 (2011)
We report on the first solution synthesi...
2'-C-cyano-2'-deoxy-1-β-D-arabinofuranosyl-cytosine (CNDAC): A mechanism-based DNA-strand-breaking antitumor nucleoside
Matsuda,Azuma
, p. 461 - 471 (1995)
The antitumor mechanism of action of 2'-...
Nucleosides and Nucleotides. 141. Chemical Stability of a new Antitumor Nucleoside, 2'-C-Cyano-2'-deoxy-1-β-D-arabino-pentofuranosylcytosine in Alkaline Medium: Formation of 2'-C-Cyano-2;-deoxy-1-β-D-ribo-pentofuranosylcytosine and Its Antitumor Activity.
Azuma, Atsushi,Hanaoka, kenji,Kurihara, Atsushi,Kobayashi, Tomowo,Miyauchi, Seiji,et al.
, p. 3391 - 3397 (1995)
We have designed 2'-C-Cyano-2'-deoxy-1-β...
Homochiral crystal generation: Via sequential dehydration and Viedma ripening
Sivakumar, Reajean,Askari, Mohammad S.,Woo, Simon,Madwar, Carolin,Ottenwaelder, Xavier,Bohle, D. Scott,Cuccia, Louis A.
, p. 4277 - 4280 (2016)
1,2-Bis(N-benzoyl-N-methylamino)benzene ...
Evidence for C-1' hydrogen abstraction from modified oligonucleotides by Fe-bleomycin
Duff,De Vroom,Geluk,Hecht,Van Der Marel,Van Boom
, p. 3350 - 3351 (1993)
-
-
Kutscher
, p. 170 (1903)
-
TET-Like Oxidation in 5-Methylcytosine and Derivatives: A Computational and Experimental Study
Jonasson, Niko S. W.,Jan?en, Rachel,Menke, Annika,Zott, Fabian L.,Zipse, Hendrik,Daumann, Lena J.
, p. 3333 - 3340 (2021/09/25)
The epigenetic marker 5-methylcytosine (...
Sources of 2,5-diaminoimidazolone lesions in DNA damage initiated by hydroxyl radical attack
Thomas, Caroline Suzanne,Pollard, Hannah Catherine,Razskazovskiy, Yuriy,Roginskaya, Marina
, p. 517 - 524 (2020/09/07)
The present study reports radiation-chem...
Monitoring the reactivity of formamide on amorphous SiO2 by in-situ UV-Raman spectroscopy and DFT modeling
Balucani, Nadia,Bonino, Francesca,Martra, Gianmario,Pantaleone, Stefano,Signorile, Matteo,Ugliengo, Piero
, (2020/05/28)
Formamide has been recognized in the lit...
A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions
Okamura, Hidenori,Becker, Sidney,Tiede, Niklas,Wiedemann, Stefan,Feldmann, Jonas,Carell, Thomas
supporting information, p. 1939 - 1942 (2019/05/02)
Herein, we report a new prebiotically pl...
71-30-7 Process route
-
-
123413-57-0
N4-benzoyl-2',3'-didehydro-2',3'-dideoxycytidine
-
-
26661-13-2
4-N-benzoylcytosine
-
-
71-30-7
Cytosine
Conditions | Yield |
---|---|
In
water;
at 40 ℃;
Rate constant;
degradation in various buffers (acidic condition, < pH 6);
|
-
-
77287-34-4,77287-35-5,60100-09-6
formamide
-
-
51953-18-5,542-27-8
pyrimidine-4(3H)-one
-
-
156-81-0
2,4-diaminopyrimidine
-
-
120-89-8
parabanic acid
-
-
108-53-2,145358-63-0,674-97-5,176772-97-7
isocytosine
-
-
71-30-7
Cytosine
-
-
144-62-7,97993-78-7
oxalic acid
-
-
113-00-8
guanidine nitrate
-
-
127-17-3
2-oxo-propionic acid
-
-
66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6
uracil
-
-
56-06-4
2,6-diaminopyrimidin-4-ol
-
-
66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine
-
-
57-13-6
urea
-
-
56-40-6,18875-39-3,25718-94-9
glycine
Conditions | Yield |
---|---|
With
copper(II) choride dihydrate;
In
water;
at 80 ℃;
for 24h;
pH=7.57;
|
1.6 mg 1.7 mg 0.0018 mg 0.1 mg 0.76 mg 0.59 mg 5.6 mg 0.3 mg 0.3 mg 0.13 mg 5 mg 3.8 mg 0.01 mg |
71-30-7 Upstream products
-
2-chloropyrimidin-4-amine
-
4-amino-2-methoxypyrimidine
-
4-ethoxypyrimidin-2-one
-
2-ethylsulfanyl-pyrimidin-4-ylamine
71-30-7 Downstream products
-
4-(Methylamino)-2(1H)-pyrimidinone
-
4-N-Acetylcytosine
-
3,4,5-trimethoxy-benzoic acid-(2-oxo-1,2-dihydro-pyrimidin-4-ylamide)
-
4-N-benzoylcytosine
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