376608-71-8
- Product Name：(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetate
- Molecular Formula：C9H9F2N.C8H8O3
- Purity：99%
- Molecular Weight：321.324
Product Details;
CasNo： 376608-71-8
Molecular Formula： C9H9F2N.C8H8O3
Hot Sale Quality Manufacturer Supply (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (R)-2-hydroxy-2-phenylacetate 376608-71-8 with Safe Transportation
- Molecular Formula:C9H9F2N.C8H8O3
- Molecular Weight:321.324
- PSA：83.55000
- LogP:3.28430
376608-71-8 Relevant articles
SUBSTITUTED ARYLUREA COMPOUNDS FOR INDUCING APOPTOSIS AND COMPOSITION FOR ANTICANCER COMPRISING THE SAME
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Paragraph 0147-0151, (2021/08/17)
The present invention relates to a subst...
Preparation method of ticagrelor key intermediate
-
Paragraph 0014, (2020/05/08)
The invention belongs to the technical f...
Preparation method of ticagrelor
-
Paragraph 0035; 0060; 0062; 0064; 0104; 0145, (2018/04/21)
The invention discloses a preparation me...
for standard auspicious Luo river intermediate preparation method
-
Paragraph 0089; 0090, (2017/08/25)
The inventiondiscloses a preparation met...
376608-71-8 Process route
-
-
220352-36-3,1006614-50-1
trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid
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-
611-71-2
(R)-Mandelic Acid
-
-
376608-71-8
trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine (2R)-2-hydroxy-2-phenylacetic acid salt
| Conditions | Yield |
|---|---|
|
trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid;
With
pyridine; thionyl chloride;
In
toluene;
at 70 ℃;
for 4h;
With
sodium azide; tetrabutylammomium bromide; sodium carbonate;
In
water; toluene;
at 0 ℃;
for 2h;
(R)-Mandelic Acid;
In
ethyl acetate;
at 17 - 25 ℃;
for 3h;
|
82% |
-
-
611-71-2
(R)-Mandelic Acid
-
-
1006614-50-1
(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl carboxylic acid
-
-
376608-71-8
trans-(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine (2R)-2-hydroxy-2-phenylacetic acid salt
| Conditions | Yield |
|---|---|
|
(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl carboxylic acid;
With
chloroformic acid ethyl ester; triethylamine;
In
water; acetone;
for 1h;
(R)-Mandelic Acid;
In
ethanol;
at 20 ℃;
for 1h;
|
80% |
376608-71-8 Upstream products
-
367-11-3
ortho-difluorobenzene
-
1345413-26-4
trans-(1R,2S)-2-(3,4-difluorophenyl)-1-nitrocyclopropane
-
611-71-2
(R)-Mandelic Acid
-
1215969-79-1
3-chloro-1-(3',4'-difluorophenyl)-propan-1-one
376608-71-8 Downstream products
-
274693-26-4
[3aR-[3aα,4α,6α,(1R,2S),6aα]]-2-[6-[[[7-(2-(3,4-difluorophenyl)cyclopropyl)]amino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenteno-1,3-dioxolan-4-yl]oxy]ethanol
-
1350749-64-2
tert-butyl ((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate
-
274693-27-5
ticagrelor
-
1383715-58-9
tert-butyl (6-chloro-5-nitro-2-(propylthio)pyrimidin-4-yl)((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)carbamate
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