149-64-4

  • Product Name:Scopolamine butylbromide
  • Molecular Formula:C21H30NO4.Br
  • Purity:99%
  • Molecular Weight:440.377
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Product Details;

CasNo: 149-64-4

Molecular Formula: C21H30NO4.Br

Appearance: White crystalline solid

Wholesale Trustworthy Manufacturer Supply Scopolamine butylbromide 149-64-4 In Stock

  • Molecular Formula:C21H30NO4.Br
  • Molecular Weight:440.377
  • Appearance/Colour:White crystalline solid 
  • Melting Point:142-144 °C 
  • PSA:59.06000 
  • LogP:-0.80420 

Scopolamine butylbromide(Cas 149-64-4) Usage

Chemical Properties

Crystalline Solid

Originator

Butylscopolamine,China Pharm

Uses

Anticholinergic. Antispasmodic

Manufacturing Process

1300 g of scopolamine base and 350 g of n-butylbromide in 600 ml acetonitrile is heated at 65°C for 160 hours. The oil obtained is dissolved in methanol. The solution is cooled and crystalline scopolamine N-n-butylbromide is filtered. After recrystallization from methanol was obtained scopolamine N-n-butylbromide with melting point 142-144°C and [α]d 20 = -20.5° (3% solution in water); yield 65%.

Therapeutic Function

Anticholinergic, Spasmolytic, Antitussive

Biochem/physiol Actions

Competitive muscarinic acetylcholine receptor antagonist; antispasmodic.

Clinical Use

Symptomatic relief of gastrointestinal or genitourinary disorders due to smooth muscle spasm Bowel colic Excessive respiratory secretions

Drug interactions

Potentially hazardous interactions with other drugs None known

Metabolism

The main metabolic pathway is the hydrolytic cleavage of the ester bond. Orally administered hyoscine butylbromide is excreted in the faeces and in the urine. Studies in man show that 2-5% of radioactive doses is eliminated renally after oral, and 0.7-1.6% after rectal administration. Approximately 90% of recovered radioactivity can be found in the faeces after oral administration. The urinary excretion of hyoscine butylbromide is less than 0.1% of the dose. The metabolites excreted via the renal route bind poorly to muscarinic receptors and are therefore not considered to contribute to the effect of the hyoscine butylbromide.

InChI:InChI=1/C21H30NO4.BrH/c1-3-4-10-22(2)17-11-15(12-18(22)20-19(17)26-20)25-21(24)16(13-23)14-8-6-5-7-9-14;/h5-9,15-20,23H,3-4,10-13H2,1-2H3;1H/q+1;/p-1/t15?,16-,17+,18+,19-,20+,22?;/m1./s1

149-64-4 Relevant articles

The synthesis of anticholinergically active N-alkylnorscopolamines and their quaternary salts with particular consideration of the bronchospasmolytic compound (-)-N-ethylnorscopolamine methobromide (Ba 253 BR)

Banholzer,Pook

, p. 217 - 228 (2007/10/02)

The synthesis of anticholinergic N-alkyl...

149-64-4 Process route

1-bromo-butane
109-65-9

1-bromo-butane

hyoscine-N-butyl bromide
149-64-4

hyoscine-N-butyl bromide

Conditions
Conditions Yield
With acetonitrile;
methyl bromide
74-83-9

methyl bromide

N-butylscopolamine
14861-14-4

N-butylscopolamine

hyoscine-N-butyl bromide
149-64-4

hyoscine-N-butyl bromide

Conditions
Conditions Yield
In acetonitrile; Ambient temperature;

149-64-4 Upstream products

  • 74-83-9
    74-83-9

    methyl bromide

  • 14861-14-4
    14861-14-4

    N-butylscopolamine

  • 109-65-9
    109-65-9

    1-bromo-butane

149-64-4 Downstream products

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